Phylogenic distribution of poly(ADP-ribose) glycohydrolase and poly(ADP-ribose)-digesting phosphodiesterase
نویسندگان
چکیده
منابع مشابه
PolyADP-ribose polymerase is a coactivator for AP-2-mediated transcriptional activation.
Overexpression of transcription factor AP-2 has been implicated in the tumorigenicity of the human teratocarcinoma cell lines PA-1 that contain an activated ras oncogene. Here we show evidence that overexpression of AP-2 sequesters transcriptional coactivators which results in self-inhibition. We identified AP-2-interacting proteins and determined whether these proteins were coactivators for AP...
متن کاملPoly(Adenosine Diphosphate Ribose) Glycohydrolase and Poly(Adenosine Diphosphate Ribose)
Green, S. & Bodansky, 0. (1965) J. Biol. Chem. 240,25742579 Haines, M. E., Johnston, I. R., Mathias, A. P. & Ridge, D. (1969) Biochem. J . 115, 881-887 Kashnig, D. M. 19 Kasper, C. B. (1969) J. Biol. Clzem. 244, 3786-3792 Mamaril, F. P., Dobrjansky, A. & Green, S. (1970) Cancer Res. 30, 352-356 Mizuno, N. S., Stoops, C. E. & Sinha, A. A. (1971) Nature (London) New Biol. 229,22-24 Siebert, G. & ...
متن کاملProteomic investigation of phosphorylation sites in poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase.
Phosphorylation is a very common post-translational modification event known to modulate a wide range of biological responses. Beyond the regulation of protein activity, the interrelation of phosphorylation with other post-translational mechanisms is responsible for the control of diverse signaling pathways. Several observations suggest that phosphorylation of poly(ADP-ribose) polymerase-1 (PAR...
متن کاملTheoretical study on the degradation of ADP-ribose polymer catalyzed by poly(ADP-ribose) glycohydrolase.
Poly(ADP-ribose) glycohydrolase (PARG) is the only enzyme responsible for the degradation of ADP-ribose polymers. Very recently, the first crystal structure of PARG was reported (Dea Slade, et al., Nature 477 (2011) 616), and a possible SN1-type-like mechanism was proposed. In this work, we present a computational study on the hydrolysis of glycosidic ribose-ribose bond catalyzed by PARG using ...
متن کاملStructure and mechanism of a canonical poly(ADP-ribose) glycohydrolase.
Poly(ADP-ribosyl)ation is a reversible post-translational protein modification involved in the regulation of a number of cellular processes including DNA repair, chromatin structure, mitosis, transcription, checkpoint activation, apoptosis and asexual development. The reversion of poly(ADP-ribosyl)ation is catalysed by poly(ADP-ribose) (PAR) glycohydrolase (PARG), which specifically targets the...
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ژورنال
عنوان ژورنال: Proceedings of the Japan Academy, Series B
سال: 2000
ISSN: 0386-2208,1349-2896
DOI: 10.2183/pjab.76.41